Section: Evolutionary Biology
Topic: Evolution, Biology of interactions, Population biology

Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum

Vantaux, Amélie1, 2  ; Yao, Franck1; Hien, Domonbabele FdS1; Guissou, Edwige1; Yameogo, Bienvenue K.1; Gouagna, Louis-Clément2; Fontenille, Didier2; Renaud, François2; Simard, Frédéric2; Constantini, Carlo2; Thomas, Fréderic2; Mouline, Karine1, 3, 2; Roche, Benjamin2, 4; Cohuet, Anna2; Dabiré, Kounbobr R1, 3; Lefèvre, Thierry1, 3, 2
1 Institut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso.
2 MIVEGEC, IRD, CNRS, University of Montpellier, Montpellier, France.
3 Laboratoire mixte international sur les vecteurs (LAMIVECT), Bobo Dioulasso, Burkina Faso.
4 Unité de Modélisation Mathématique et Informatique des Systèmes complexes (UMMISCO), UMI IRD/UPMC209, Bondy, France.

Corresponding author(s): Vantaux, Amélie (amelie.vantaux@gmail.com)

10.24072/pcjournal.13 - Peer Community Journal, Volume 1 (2021), article no. e13.

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Whether the malaria parasite Plasmodium falciparum can manipulate mosquito host choice in ways that enhance parasite transmission toward humans is unknown. We assessed the influence of P. falciparum on the blood-feeding behaviour of three of its major vectors (Anopheles coluzzii, An. gambiae and An. arabiensis) in Burkina Faso. Host preference assays using odour-baited traps revealed no effect of infection on mosquito long-range anthropophily. However, the identification of the blood meal origin of mosquitoes showed that females carrying sporozoites, the mature transmissible stage of the parasite, displayed a 24% increase in anthropophagy compared to both females harbouring oocysts, the parasite immature stage, and uninfected individuals. Using a mathematical model, we further showed that this increased anthropophagy in infectious females resulted in a 250% increase in parasite transmission potential, everything else being equal. This important epidemiological consequence highlights the importance of vector control tools targeting infectious females.

Published online:
DOI: 10.24072/pcjournal.13
Type: Research article

Vantaux, Amélie 1, 2; Yao, Franck 1; Hien, Domonbabele FdS 1; Guissou, Edwige 1; Yameogo, Bienvenue K. 1; Gouagna, Louis-Clément 2; Fontenille, Didier 2; Renaud, François 2; Simard, Frédéric 2; Constantini, Carlo 2; Thomas, Fréderic 2; Mouline, Karine 1, 3, 2; Roche, Benjamin 2, 4; Cohuet, Anna 2; Dabiré, Kounbobr R 1, 3; Lefèvre, Thierry 1, 3, 2

1 Institut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso.
2 MIVEGEC, IRD, CNRS, University of Montpellier, Montpellier, France.
3 Laboratoire mixte international sur les vecteurs (LAMIVECT), Bobo Dioulasso, Burkina Faso.
4 Unité de Modélisation Mathématique et Informatique des Systèmes complexes (UMMISCO), UMI IRD/UPMC209, Bondy, France.
License: CC-BY 4.0
Copyrights: The authors retain unrestricted copyrights and publishing rights 
@article{10_24072_pcjournal_13,
     author = {Vantaux, Am\'elie and Yao, Franck and Hien, Domonbabele FdS and Guissou, Edwige and Yameogo, Bienvenue K. and Gouagna, Louis-Cl\'ement and Fontenille, Didier and Renaud, Fran\c{c}ois and Simard, Fr\'ed\'eric and Constantini, Carlo and Thomas, Fr\'ederic and Mouline, Karine and Roche, Benjamin and Cohuet, Anna and Dabir\'e, Kounbobr R and Lef\`evre, Thierry},
     title = {Field evidence for manipulation of mosquito host selection by the human malaria parasite, {\protect\emph{Plasmodium} falciparum}},
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     eid = {e13},
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     volume = {1},
     year = {2021},
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AU  - Yao, Franck
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AU  - Yameogo, Bienvenue K.
AU  - Gouagna, Louis-Clément
AU  - Fontenille, Didier
AU  - Renaud, François
AU  - Simard, Frédéric
AU  - Constantini, Carlo
AU  - Thomas, Fréderic
AU  - Mouline, Karine
AU  - Roche, Benjamin
AU  - Cohuet, Anna
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AU  - Lefèvre, Thierry
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%A Gouagna, Louis-Clément
%A Fontenille, Didier
%A Renaud, François
%A Simard, Frédéric
%A Constantini, Carlo
%A Thomas, Fréderic
%A Mouline, Karine
%A Roche, Benjamin
%A Cohuet, Anna
%A Dabiré, Kounbobr R
%A Lefèvre, Thierry
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Vantaux, Amélie; Yao, Franck; Hien, Domonbabele FdS; Guissou, Edwige; Yameogo, Bienvenue K.; Gouagna, Louis-Clément; Fontenille, Didier; Renaud, François; Simard, Frédéric; Constantini, Carlo; Thomas, Fréderic; Mouline, Karine; Roche, Benjamin; Cohuet, Anna; Dabiré, Kounbobr R; Lefèvre, Thierry. Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum. Peer Community Journal, Volume 1 (2021), article  no. e13. doi : 10.24072/pcjournal.13. https://peercommunityjournal.org/articles/10.24072/pcjournal.13/

PCI peer reviews and recommendation, and links to data, scripts, code and supplementary information: 10.24072/pci.evolbiol.100057

Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.

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