Section: Neuroscience
Topic:
Neuroscience,
Genetics/Genomics
Functional correlates of immediate early gene expression in mouse visual cortex
Corresponding author(s): Keller, Georg B. (georg.keller@fmi.ch)
10.24072/pcjournal.156 - Peer Community Journal, Volume 2 (2022), article no. e45.
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During visual development, response properties of layer 2/3 neurons in visual cortex are shaped by experience. Both visual and visuomotor experience are necessary to coordinate the integration of bottom-up visual input and top-down motor-related input. Whether visual and visuomotor experience engage different plasticity mechanisms, possibly associated with the two separate input pathways, is still unclear. To begin addressing this, we measured the expression level of three different immediate early genes (IEG) (c-fos, egr1 or Arc) and neuronal activity in layer 2/3 neurons of visual cortex before and after a mouse’s first visual exposure in life, and subsequent visuomotor learning. We found that expression levels of all three IEGs correlated positively with neuronal activity, but that first visual and first visuomotor exposure resulted in differential changes in IEG expression patterns. In addition, IEG expression levels differed depending on whether neurons exhibited primarily visually driven or motor-related activity. Neurons with strong motor-related activity preferentially expressed EGR1, while neurons that developed strong visually driven activity preferentially expressed Arc. Our findings are consistent with the interpretation that bottom-up visual input and top-down motor-related input are associated with different IEG expression patterns and hence possibly also with different plasticity pathways.
Type: Research article
Mahringer, David 1, 2; Zmarz, Pawel 1, 2, 3; Okuno, Hiroyuki 4; Bito, Haruhiko 5; Keller, Georg B. 1, 2
CC-BY 4.0
@article{10_24072_pcjournal_156,
author = {Mahringer, David and Zmarz, Pawel and Okuno, Hiroyuki and Bito, Haruhiko and Keller, Georg B.},
title = {Functional correlates of immediate early gene expression in mouse visual cortex},
journal = {Peer Community Journal},
eid = {e45},
publisher = {Peer Community In},
volume = {2},
year = {2022},
doi = {10.24072/pcjournal.156},
url = {https://peercommunityjournal.org/articles/10.24072/pcjournal.156/}
}
TY - JOUR AU - Mahringer, David AU - Zmarz, Pawel AU - Okuno, Hiroyuki AU - Bito, Haruhiko AU - Keller, Georg B. TI - Functional correlates of immediate early gene expression in mouse visual cortex JO - Peer Community Journal PY - 2022 VL - 2 PB - Peer Community In UR - https://peercommunityjournal.org/articles/10.24072/pcjournal.156/ DO - 10.24072/pcjournal.156 ID - 10_24072_pcjournal_156 ER -
%0 Journal Article %A Mahringer, David %A Zmarz, Pawel %A Okuno, Hiroyuki %A Bito, Haruhiko %A Keller, Georg B. %T Functional correlates of immediate early gene expression in mouse visual cortex %J Peer Community Journal %D 2022 %V 2 %I Peer Community In %U https://peercommunityjournal.org/articles/10.24072/pcjournal.156/ %R 10.24072/pcjournal.156 %F 10_24072_pcjournal_156
Mahringer, David; Zmarz, Pawel; Okuno, Hiroyuki; Bito, Haruhiko; Keller, Georg B. Functional correlates of immediate early gene expression in mouse visual cortex. Peer Community Journal, Volume 2 (2022), article no. e45. doi : 10.24072/pcjournal.156. https://peercommunityjournal.org/articles/10.24072/pcjournal.156/
PCI peer reviews and recommendation, and links to data, scripts, code and supplementary information: 10.24072/pci.neuro.100005
Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.
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