Evolutionary Biology

Treating symptomatic infections and the co-evolution of virulence and drug resistance

10.24072/pcjournal.38 - Peer Community Journal, Volume 1 (2021), article no. e47.

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Antimicrobial therapeutic treatments are by definition applied after the onset of symptoms, which tend to correlate with infection severity. Using mathematical epidemiology models, I explore how this link affects the coevolutionary dynamics between the virulence of an infection, measured via host mortality rate, and its susceptibility to chemotherapy. I show that unless resistance pre-exists in the population, drug-resistant infections are initially more virulent than drug-sensitive ones. As the epidemic unfolds, virulence is more counter-selected in drug-sensitive than in drug-resistant infections. This difference decreases over time and, eventually, the exact shape of genetic trade-offs govern long-term evolutionary dynamics. Using adaptive dynamics, I show that two types of evolutionary stable strategies (ESS) may be reached in the context of this simple model and that, depending on the parameter values, an ESS may only be locally stable. In general, the more the treatment rate increases with virulence, the lower the ESS value. Overall, both on the short-term and long-term, having treatment rate depend on infection virulence tend to favour less virulent strains in drug-sensitive infections. These results highlight the importance of the feedbacks between epidemiology, public health policies and parasite evolution, and have implications for the monitoring of virulence evolution.
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DOI: 10.24072/pcjournal.38
Alizon, Samuel 1, 2

1 Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Université PSL, Paris, France
2 MIVEGEC, CNRS, IRD, Université de Montpellier, France
License: CC-BY 4.0
Copyrights: The authors retain unrestricted copyrights and publishing rights
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Alizon, Samuel. Treating symptomatic infections and the co-evolution of virulence and drug resistance. Peer Community Journal, Volume 1 (2021), article  no. e47. doi : 10.24072/pcjournal.38. https://peercommunityjournal.org/articles/10.24072/pcjournal.38/

Peer reviewed and recommended by PCI : 10.24072/pci.evolbiol.100113

Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.

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