Section: Genomics
Topic: Evolution, Genetics/genomics
Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps
10.24072/pcjournal.406 - Peer Community Journal, Volume 4 (2024), article no. e36.
Get full text PDF Peer reviewed and recommended by PCI
Animal venoms and other protein-based secretions that perform a variety of functions, from predation to defense, are highly complex cocktails of bioactive compounds. Gene duplication, accompanied by modification of the expression and/or function of one of the duplicates under the action of positive selection, followed by further duplication to produce multigene families of toxins is a well-documented process in venomous animals. This evolutionary model has been less described in parasitoid wasps, which use maternal fluids, including venom, to protect their eggs from encapsulation by the host immune system. Here, we evidence the convergent recruitment and accelerated evolution of two multigene families of RhoGAPs presumably involved in virulence in two unrelated parasitoid wasp species, Leptopilina boulardi (Figitidae) and Venturia canescens (Icheumonidae). In both species, these RhoGAPs are associated with vesicles that act as transport systems to deliver virulence factors, but are produced in different tissues: the venom gland in Leptopilina sp. and the ovarian calyx in V. canescens. We show that the gene encoding the cellular RacGAP1 is at the origin of the virulent RhoGAP families found in Leptopilina sp. and V. canescens. We also show that both RhoGAP families have undergone evolution under positive selection and that almost all of these RhoGAPs lost their GAP activity and GTPase binding ability due to substitutions in key amino acids. These results suggest an accelerated evolution and functional diversification of these vesicle-associated RhoGAPs in the two phylogenetically distant parasitoid species. The potential new function(s) and the exact mechanism of action of these proteins in host cells remain to be elucidated.
Type: Research article
CC-BY 4.0
@article{10_24072_pcjournal_406,
author = {Colinet, Dominique and Cavigliasso, Fanny and Leobold, Matthieu and Pichon, Apolline and Urbach, Serge and Cazes, Dominique and Poullet, Marine and Belghazi, Maya and Volkoff, Anne-Nathalie and Drezen, Jean-Michel and Gatti, Jean-Luc and Poiri\'e, Maryl\`ene},
title = {Convergent origin and accelerated evolution of vesicle-associated {RhoGAP} proteins in two unrelated parasitoid wasps},
journal = {Peer Community Journal},
eid = {e36},
publisher = {Peer Community In},
volume = {4},
year = {2024},
doi = {10.24072/pcjournal.406},
language = {en},
url = {https://peercommunityjournal.org/articles/10.24072/pcjournal.406/}
}
TY - JOUR AU - Colinet, Dominique AU - Cavigliasso, Fanny AU - Leobold, Matthieu AU - Pichon, Apolline AU - Urbach, Serge AU - Cazes, Dominique AU - Poullet, Marine AU - Belghazi, Maya AU - Volkoff, Anne-Nathalie AU - Drezen, Jean-Michel AU - Gatti, Jean-Luc AU - Poirié, Marylène TI - Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps JO - Peer Community Journal PY - 2024 VL - 4 PB - Peer Community In UR - https://peercommunityjournal.org/articles/10.24072/pcjournal.406/ DO - 10.24072/pcjournal.406 LA - en ID - 10_24072_pcjournal_406 ER -
%0 Journal Article %A Colinet, Dominique %A Cavigliasso, Fanny %A Leobold, Matthieu %A Pichon, Apolline %A Urbach, Serge %A Cazes, Dominique %A Poullet, Marine %A Belghazi, Maya %A Volkoff, Anne-Nathalie %A Drezen, Jean-Michel %A Gatti, Jean-Luc %A Poirié, Marylène %T Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps %J Peer Community Journal %D 2024 %V 4 %I Peer Community In %U https://peercommunityjournal.org/articles/10.24072/pcjournal.406/ %R 10.24072/pcjournal.406 %G en %F 10_24072_pcjournal_406
Colinet, Dominique; Cavigliasso, Fanny; Leobold, Matthieu; Pichon, Apolline; Urbach, Serge; Cazes, Dominique; Poullet, Marine; Belghazi, Maya; Volkoff, Anne-Nathalie; Drezen, Jean-Michel; Gatti, Jean-Luc; Poirié, Marylène. Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps. Peer Community Journal, Volume 4 (2024), article no. e36. doi : 10.24072/pcjournal.406. https://peercommunityjournal.org/articles/10.24072/pcjournal.406/
Peer reviewed and recommended by PCI : 10.24072/pci.genomics.100248
Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.
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