Section: Ecotoxicology & Environmental Chemistry
Topic: Ecology, Environmental sciences, Physiology

Molecular response to multiple trace element contamination of the European sardine

Beauvieux, Anaïs1  ; Fromentin, Jean-Marc1 ; Saraux, Claire2 ; Romero, Diego3; Couffin, Nathan2, 4; Brown, Adrien2, 4; Metral, Luisa1; Bertile, Fabrice2, 4 ; Schull, Quentin1 
1 MARBEC, Univ Montpellier, CNRS, Ifremer, IRD, Sète, France
2 Université de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France
3 Toxicology Department, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, Spain
4 Infrastructure Nationale de Protéomique ProFI, FR2048 CNRS CEA, Strasbourg 67087, France

10.24072/pcjournal.450 - Peer Community Journal, Volume 4 (2024), article no. e74.

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In marine ecosystems, the presence of trace elements resulting from anthropogenic activities has raised concerns regarding their potential effects on marine organisms. This study delves into the intricate relationship between trace element contamination and the physiological responses of a key marine species in the Mediterranean Sea: the European sardine. Since 2008, this species has been experiencing a significant crisis in the region, prompting numerous studies to investigate the potential factors behind the dramatic decline in sardines size, age, and body condition. However, thorough information on chemical contamination by trace elements and its physiological impact on this species was lacking. We found evidence for the accumulation of multiple elements in sardines, with a light East-West contamination gradient within the Gulf of Lions. While macro-physiological parameters (i.e. body condition) were not affected by contamination, pathways involved in cellular organization and response to stress were clearly upregulated, particularly in the liver, but also in muscle. In addition, a global upregulation in processes linked to the immune system, lipid homeostasis and oxidative stress was recorded in the liver. The associated energetic cost may add a substantial burden to sardines that already face multi-factorial constraints. This study also allows to pinpoint biomarkers of exposure and effects that may be important for monitoring Mediterranean sardine health. The results of this study and particularly the complex changes in protein expression demonstrate the need for future studies to test the concomitant effects of multiple stressors acting simultaneously, including large scale contamination.

Published online:
DOI: 10.24072/pcjournal.450
Type: Research article
Keywords: Cocktail effect, Ecotoxicology, Gulf of Lions, Sardina pilchardus, Shotgun proteomic

Beauvieux, Anaïs 1; Fromentin, Jean-Marc 1; Saraux, Claire 2; Romero, Diego 3; Couffin, Nathan 2, 4; Brown, Adrien 2, 4; Metral, Luisa 1; Bertile, Fabrice 2, 4; Schull, Quentin 1

1 MARBEC, Univ Montpellier, CNRS, Ifremer, IRD, Sète, France
2 Université de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France
3 Toxicology Department, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, Spain
4 Infrastructure Nationale de Protéomique ProFI, FR2048 CNRS CEA, Strasbourg 67087, France
License: CC-BY 4.0
Copyrights: The authors retain unrestricted copyrights and publishing rights 
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     title = {Molecular response to multiple trace element contamination of the {European} sardine},
     journal = {Peer Community Journal},
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Beauvieux, Anaïs; Fromentin, Jean-Marc; Saraux, Claire; Romero, Diego; Couffin, Nathan; Brown, Adrien; Metral, Luisa; Bertile, Fabrice; Schull, Quentin. Molecular response to multiple trace element contamination of the European sardine. Peer Community Journal, Volume 4 (2024), article  no. e74. doi : 10.24072/pcjournal.450. https://peercommunityjournal.org/articles/10.24072/pcjournal.450/

PCI peer reviews and recommendation, and links to data, scripts, code and supplementary information: 10.24072/pci.ecotoxenvchem.100210

Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.

[1] Alekseenko, E.; Thouvenin, B.; Tronczyński, J.; Carlotti, F.; Garreau, P.; Tixier, C.; Baklouti, M. Modeling of PCB Trophic Transfer in the Gulf of Lions; 3D Coupled Model Application, Marine Pollution Bulletin, Volume 128 (2018) no. February, pp. 140-155 | DOI

[2] Apraiz, I.; Mi, J.; Cristobal, S. Identification of Proteomic Signatures of Exposure to Marine Pollutants in Mussels (Mytilus Edulis), Molecular and Cellular Proteomics, Volume 5 (2006) no. 7, pp. 1274-1285 | DOI

[3] Asaduzzaman, K.; Khandaker, M. U.; Binti Baharudin, N. A.; Amin, Y. B. M.; Farook, M. S.; Bradley, D.; Mahmoud, O. Heavy Metals in Human Teeth Dentine: A Bio-Indicator of Metals Exposure and Environmental Pollution, Chemosphere, Volume 176 (2017), pp. 221-230 | DOI

[4] Asker, N.; Kristiansson, E.; Albertsson, E.; Larsson, D. J.; Förlin, L. Hepatic Transcriptome Profiling Indicates Differential mRNA Expression of Apoptosis and Immune Related Genes in Eelpout (Zoarces Viviparus) Caught at Göteborg Harbor, Sweden, Aquatic Toxicology, Volume 130–131 (2013), pp. 58-67 | DOI

[5] Aslam, S.; Yousafzai, A. M. Chromium Toxicity in Fish: A Review Article, Journal of Entomology and Zoology Studies, Volume 5 (2017) no. 3, pp. 1483-1488

[6] Authman, M. M. N. Environmental and Experimental Studies of Aluminium Toxicity on the Liver of Oreochromis Niloticus (Linnaeus, 1757) Fish, Life Science Journal, Volume 8 (2011) no. 4, pp. 764-776

[7] Bahl, A.; Ibrahim, C.; Plate, K.; Haase, A.; Dengjel, J.; Nymark, P.; Dumit, V. I. PROTEOMAS : A Workflow Enabling Harmonized Proteomic Meta - Analysis and Proteomic Signature Mapping, Journal of Cheminformatics (2023), pp. 1-17 | DOI

[8] Baker, E.; Sevaldsen, P.; Kurvits, T. State and Pressures of the Marine and Coastal Mediterranean Environment, European Environment Agency, 2013 no. 5, pp. 1-44

[9] Bawuro, A. A.; Voegborlo, R. B.; Adimado, A. A. Bioaccumulation of Heavy Metals in Some Tissues of Fish in Lake Geriyo, Adamawa State, Nigeria, Journal of Environmental and Public Health, Volume 2018 (2018), pp. 1-7 | DOI

[10] Beauvieux, A.; Fromentin, J.-M.; Saraux, C.; Romero, D.; Couffin, N.; Brown, A.; Metral, L.; Bertile, F.; Schull, Q. Supplementary materials: Molecular response to multiple trace-element contamination of the European sardine., Zenodo, 2024 | DOI

[11] Beauvieux, A.; Fromentin, J.-M.; Romero, D.; Couffin, N.; Brown, A.; Metral, L.; Bourjea, J.; Bertile, F.; Schull, Q. Molecular Fingerprint of Gilthead Seabream Physiology in Response to Pollutant Mixtures in the Wild, Environmental Pollution, Volume 340 (2024), p. 122789 | DOI

[12] Beauvieux, A.; Fromentin, J.-M.; Saraux, C.; Romero, D.; Couffin, N.; Brown, A.; Metral, L.; Bertile, F.; Schull, Q. Molecular response to multiple trace element contamination of the European sardine, bioRxiv, 2024 | DOI

[13] Beauvieux, A.; Queiros, Q.; Metral, L.; Dutto, G.; Gasset, E.; Criscuolo, F.; Fromentin, J. M.; Saraux, C.; Schull, Q. Energy Allocation Trade-Offs between Life-History Traits in the Mediterranean Sardine: An Ecophysiological Approach, Marine Ecology Progress Series, Volume 701 (2022) no. Stearns 1989, pp. 99-118 | DOI

[14] Benninghoff, A. D. Toxicoproteomics - The next Step in the Evolution of Environmental Biomarkers?, Toxicological Sciences, Volume 95 (2007) no. 1, pp. 1-4 | DOI

[15] Bervoets, L.; Blust, R. Metal Concentrations in Water, Sediment and Gudgeon (Gobio Gobio) from a Pollution Gradient: Relationship with Fish Condition Factor, Environmental Pollution, Volume 126 (2003) no. 1, pp. 9-19 | DOI

[16] Bervoets, L.; Knaepkens, G.; Eens, M.; Blust, R. Fish Community Responses to Metal Pollution, Environmental Pollution, Volume 138 (2005) no. 2, pp. 338-349 | DOI

[17] Bindea, G.; Mlecnik, B.; Hackl, H.; Charoentong, P.; Tosolini, M.; Kirilovsky, A.; Fridman, W.-H.; Pagès, F.; Trajanoski, Z.; Galon, J. ClueGO: A Cytoscape Plug-in to Decipher Functionally Grouped Gene Ontology and Pathway Annotation Networks, Bioinformatics (Oxford, England), Volume 25 (2009) no. 8, pp. 1091-1093 | DOI

[18] Blewett, T. A.; Leonard, E. M. Mechanisms of Nickel Toxicity to Fish and Invertebrates in Marine and Estuarine Waters, Environmental Pollution, Volume 223 (2017), pp. 311-322 | DOI

[19] Bodiguel, X.; Loizeau, V.; Le Guellec, A.-M.; Roupsard, F.; Philippon, X.; Mellon-Duval, C. Influence of Sex, Maturity and Reproduction on PCB and p,p$\prime$DDE Concentrations and Repartitions in the European Hake (Merluccius Merluccius, L.) from the Gulf of Lions (N.W. Mediterranean), Science of The Total Environment, Volume 408 (2009) no. 2, pp. 304-311 | DOI

[20] Bohne-Kjersem, A.; Skadsheim, A.; Goksøyr, A.; Grøsvik, B. E. Candidate Biomarker Discovery in Plasma of Juvenile Cod (Gadus Morhua) Exposed to Crude North Sea Oil, Alkyl Phenols and Polycyclic Aromatic Hydrocarbons (PAHs), Marine Environmental Research, Volume 68 (2009) no. 5, pp. 268-277 | DOI

[21] Bouchoucha, M. SUCHI Med 2021 (2021) | DOI

[22] Bourdeix, J.; Hattab, T. Pelmed - Pelagiques Mediterranée, cruise (1985) | DOI

[23] Boyle, E. A.; Chapnick, S. D.; Bai, X. X.; Spivack, A. Trace Metal Enrichments in the Mediterranean Sea, Earth and Planetary Science Letters, Volume 74 (1985) no. 4, pp. 405-419 | DOI

[24] Braasch, I.; Gehrke, A. R.; Smith, J. J.; Kawasaki, K.; Manousaki, T.; Pasquier, J.; Amores, A.; Desvignes, T.; Batzel, P.; Catchen, J.; Berlin, A. M.; Campbell, M. S.; Barrell, D.; Martin, K. J.; Mulley, J. F.; Ravi, V.; Lee, A. P.; Nakamura, T.; Chalopin, D.; Fan, S.; Wcisel, D.; Cañestro, C.; Sydes, J.; Beaudry, F. E. G.; Sun, Y.; Hertel, J.; Beam, M. J.; Fasold, M.; Ishiyama, M.; Johnson, J.; Kehr, S.; Lara, M.; Letaw, J. H.; Litman, G. W.; Litman, R. T.; Mikami, M.; Ota, T.; Saha, N. R.; Williams, L.; Stadler, P. F.; Wang, H.; Taylor, J. S.; Fontenot, Q.; Ferrara, A.; Searle, S. M. J.; Aken, B.; Yandell, M.; Schneider, I.; Yoder, J. A.; Volff, J.-N.; Meyer, A.; Amemiya, C. T.; Venkatesh, B.; Holland, P. W. H.; Guiguen, Y.; Bobe, J.; Shubin, N. H.; Di Palma, F.; Alföldi, J.; Lindblad-Toh, K.; Postlethwait, J. H. The Spotted Gar Genome Illuminates Vertebrate Evolution and Facilitates Human-Teleost Comparisons, Nature Genetics, Volume 48 (2016) no. 4, pp. 427-437 | DOI

[25] Broche, P.; Devenon, J.-L.; Forget, P.; de Maistre, J.-C.; Naudin, J.-J.; Cauwet, G. Experimental Study of the Rhone Plume. Part I: Physics and Dynamics, Oceanologica Acta, Volume 21 (1998) no. 6, pp. 725-738 | DOI

[26] Brosset, P.; Fromentin, J. M.; Ménard, F.; Pernet, F.; Bourdeix, J. H.; Bigot, J. L.; Van Beveren, E.; Pérez Roda, M. A.; Choy, S.; Saraux, C. Measurement and Analysis of Small Pelagic Fish Condition: A Suitable Method for Rapid Evaluation in the Field, Journal of Experimental Marine Biology and Ecology, Volume 462 (2015), pp. 90-97 | DOI

[27] Brosset, P.; Fromentin, J.-M.; Van Beveren, E.; Lloret, J.; Marques, V.; Basilone, G.; Bonanno, A.; Carpi, P.; Donato, F.; Čikeš Keč, V.; De Felice, A.; Ferreri, R.; Gašparević, D.; Giráldez, A.; Gücü, A.; Iglesias, M.; Leonori, I.; Palomera, I.; Somarakis, S.; Tičina, V.; Torres, P.; Ventero, A.; Zorica, B.; Ménard, F.; Saraux, C. Spatio-Temporal Patterns and Environmental Controls of Small Pelagic Fish Body Condition from Contrasted Mediterranean Areas, Progress in Oceanography, Volume 151 (2017) no. February, pp. 149-162 | DOI

[28] Brosset, P.; Le Bourg, B.; Costalago, D.; BǍnaru, D.; Van Beveren, E.; Bourdeix, J. H.; Fromentin, J. M.; Ménard, F.; Saraux, C. Linking Small Pelagic Dietary Shifts with Ecosystem Changes in the Gulf of Lions, Marine Ecology Progress Series, Volume 554 (2016), pp. 157-171 | DOI

[29] Brosset, P.; Ménard, F.; Fromentin, J. M.; Bonhommeau, S.; Ulses, C.; Bourdeix, J. H.; Bigot, J. L.; Van Beveren, E.; Roos, D.; Saraux, C. Influence of Environmental Variability and Age on the Body Condition of Small Pelagic Fish in the Gulf of Lions, Marine Ecology Progress Series, Volume 529 (2015), pp. 219-231 | DOI

[30] Bucchia, M.; Camacho, M.; Santos, M. R.; Boada, L. D.; Roncada, P.; Mateo, R.; Ortiz-Santaliestra, M. E.; Rodríguez-Estival, J.; Zumbado, M.; Orós, J.; Henríquez-Hernández, L. A.; García-Álvarez, N.; Luzardo, O. P. Plasma Levels of Pollutants Are Much Higher in Loggerhead Turtle Populations from the Adriatic Sea than in Those from Open Waters (Eastern Atlantic Ocean), Science of the Total Environment, Volume 523 (2015), pp. 161-169 | DOI

[31] Canli, M.; Atli, G. The Relationships between Heavy Metal (Cd, Cr, Cu, Fe, Pb, Zn) Levels and the Size of Six Mediterranean Fish Species, Environmental Pollution, Volume 121 (2003) no. 1, pp. 129-136 | DOI

[32] Carapito, C.; Burel, A.; Guterl, P.; Walter, A.; Varrier, F.; Bertile, F.; Van Dorsselaer, A. MSDA, a Proteomics Software Suite for in-Depth Mass Spectrometry Data Analysis Using Grid Computing, Proteomics, Volume 14 (2014) no. 9, pp. 1014-1019 | DOI

[33] Celander, M. C. Cocktail Effects on Biomarker Responses in Fish, Aquatic Toxicology, Volume 105 (2011) no. 3-4, pp. 72-77 | DOI

[34] Chen, L.; Liu, L.; Luo, Y.; Huang, S. MAPK and mTOR Pathways Are Involved in Cadmium-induced Neuronal Apoptosis, Journal of Neurochemistry, Volume 105 (2008) no. 1, pp. 251-261 | DOI

[35] Chouvelon, T.; Cresson, P.; Bouchoucha, M.; Brach-Papa, C.; Bustamante, P.; Crochet, S.; Marco-Miralles, F.; Thomas, B.; Knoery, J. Oligotrophy as a Major Driver of Mercury Bioaccumulation in Medium-to High-Trophic Level Consumers: A Marine Ecosystem-Comparative Study, Environmental Pollution, Volume 233 (2018), pp. 844-854 | DOI

[36] Chouvelon, T.; Strady, E.; Harmelin-Vivien, M.; Radakovitch, O.; Brach-Papa, C.; Crochet, S.; Knoery, J.; Rozuel, E.; Thomas, B.; Tronczynski, J.; Chiffoleau, J.-F. Patterns of Trace Metal Bioaccumulation and Trophic Transfer in a Phytoplankton-Zooplankton-Small Pelagic Fish Marine Food Web, Marine Pollution Bulletin, Volume 146 (2019), pp. 1013-1030 | DOI

[37] Cossa, D.; Coquery, M. The Mediterranean Mercury Anomaly, a Geochemical or a BiologocalIssue, The Mediterranean Sea, Springer Berlin Heidelberg, Berlin, Heidelberg, 2005, pp. 177-208 | DOI

[38] Cossa, D.; Durrieu de Madron, X.; Schäfer, J.; Lanceleur, L.; Guédron, S.; Buscail, R.; Thomas, B.; Castelle, S.; Naudin, J.-J. The Open Sea as the Main Source of Methylmercury in the Water Column of the Gulf of Lions (Northwestern Mediterranean Margin), Geochimica et Cosmochimica Acta, Volume 199 (2017), pp. 222-237 | DOI

[39] Cox, J.; Hein, M. Y.; Luber, C. A.; Paron, I.; Nagaraj, N.; Mann, M. Accurate Proteome-Wide Label-Free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ, Molecular and Cellular Proteomics, Volume 13 (2014) no. 9, pp. 2513-2526 | DOI

[40] Danovaro, R. Pollution Threats in the Mediterranean Sea : An Overview, Chemistry and Ecology, Volume 19 (2003) no. 1, pp. 15-32 | DOI

[41] Denslow, N. D.; Knoebl, I.; Larkin, P. Chapter 3 Approaches in Proteomics and Genomics for Eco-Toxicology, Biochemistry and Molecular Biology of Fishes, Volume 6 (2005) no. C, pp. 85-116 | DOI

[42] Dethloff, G. M.; Bailey, H. C.; Ma, K. J. Effects of Dissolved Copper on Select Hematological, Biochemical, and Immunological Parameters of Wild Rainbow Trout ( Oncorhynchus mykiss ), Archives of Environmental Contamination and Toxicology, Volume 40 (2001) no. 3, pp. 371-380 | DOI

[43] Dixon, G. B.; Davies, S. W.; Aglyamova, G. V.; Meyer, E.; Bay, L. K.; Matz, M. V. Genomic Determinants of Coral Heat Tolerance across Latitudes, Science, Volume 348 (2015) no. 6242, pp. 1460-1462 | DOI

[44] Downs, C. A.; Richmond, R. H.; Mendiola, W. J.; Rougée, L.; Ostrander, G. K. Cellular Physiological Effects of the MV Kyowa Violet Fuel-Oil Spill on the Hard Coral, Porites Lobata, Environmental Toxicology and Chemistry, Volume 25 (2006) no. 12, pp. 3171-3180 | DOI

[45] Durrieu de Madron, X.; Guieu, C.; Sempéré, R.; Conan, P.; Cossa, D.; D'Ortenzio, F.; Estournel, C.; Gazeau, F.; Rabouille, C.; Stemmann, L.; Bonnet, S.; Diaz, F.; Koubbi, P.; Radakovitch, O.; Babin, M.; Baklouti, M.; Bancon-Montigny, C.; Belviso, S.; Bensoussan, N.; Bonsang, B.; Bouloubassi, I.; Brunet, C.; Cadiou, J.-F.; Carlotti, F.; Chami, M.; Charmasson, S.; Charrière, B.; Dachs, J.; Doxaran, D.; Dutay, J.-C.; Elbaz-Poulichet, F.; Eléaume, M.; Eyrolles, F.; Fernandez, C.; Fowler, S.; Francour, P.; Gaertner, J.; Galzin, R.; Gasparini, S.; Ghiglione, J.-F.; Gonzalez, J.-L.; Goyet, C.; Guidi, L.; Guizien, K.; Heimbürger, L.-E.; Jacquet, S.; Jeffrey, W.; Joux, F.; Le Hir, P.; Leblanc, K.; Lefèvre, D.; Lejeusne, C.; Lemé, R.; Loÿe-Pilot, M.-D.; Mallet, M.; Méjanelle, L.; Mélin, F.; Mellon, C.; Mérigot, B.; Merle, P.-L.; Migon, C.; Miller, W.; Mortier, L.; Mostajir, B.; Mousseau, L.; Moutin, T.; Para, J.; Pérez, T.; Petrenko, A.; Poggiale, J.-C.; Prieur, L.; Pujo-Pay, M.; Pulido-Villena; Raimbault, P.; Rees, A.; Ridame, C.; Rontani, J.-F.; Ruiz Pino, D.; Sicre, M.; Taillandier, V.; Tamburini, C.; Tanaka, T.; Taupier-Letage, I.; Tedetti, M.; Testor, P.; Thébault, H.; Thouvenin, B.; Touratier, F.; Tronczynski, J.; Ulses, C.; Van Wambeke, F.; Vantrepotte, V.; Vaz, S.; Verney, R. Marine Ecosystems' Responses to Climatic and Anthropogenic Forcings in the Mediterranean, Progress in Oceanography, Volume 91 (2011) no. 2, pp. 97-166 | DOI

[46] Dydak, U.; Jiang, Y. M.; Long, L. L.; Zhu, H.; Chen, J.; Li, W. M.; Edden, R. A.; Hu, S.; Fu, X.; Long, Z.; Mo, X. A.; Meier, D.; Harezlak, J.; Aschner, M.; Murdoch, J. B.; Zheng, W. In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese, Environmental Health Perspectives, Volume 119 (2011) no. 2, pp. 219-224 | DOI

[47] Epel, E. S.; Blackburn, E. H.; Lin, J.; Dhabhar, F. S.; Adler, N. E.; Morrow, J. D.; Cawthon, R. M. Accelerated Telomere Shortening in Response to Life Stress, Proceedings of the National Academy of Sciences of the United States of America, Volume 101 (2004) no. 49, pp. 17312-17315 | DOI

[48] Exley, C.; Chappell, J.; Birchall, J. A Mechanism for Acute Aluminium Toxicity in Fish, Journal of Theoretical Biology, Volume 151 (1991) no. 3, pp. 417-428 | DOI

[49] Farag, A. M.; Woodward, D. F.; Goldstein, J. N.; Brumbaugh, W.; Meyer, J. S. Concentrations of Metals Associated with Mining Waste in Sediments, Biofilm, Benthic Macroinvertebrates, and Fish from the Coeur d'Alene River Basin, Idaho, Archives of Environmental Contamination and Toxicology, Volume 34 (1998) no. 2, pp. 119-127 | DOI

[50] Feuilloley, G.; Fromentin, J. M.; Stemmann, L.; Demarcq, H.; Estournel, C.; Saraux, C. Concomitant Changes in the Environment and Small Pelagic Fish Community of the Gulf of Lions, Progress in Oceanography, Volume 186 (2020) no. June, p. 102375 | DOI

[51] Folch, J.; Lees, M.; Stanley, G. S. A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues, Journal of Biological Chemistry, Volume 226 (1957) no. 1, pp. 497-509 | DOI

[52] Friberg, L.; Nordberg, G. F.; Vouk, V. B. Handbook of the Toxicology of Metals, Elsevier/North-Holland Biomedical Press

[53] Gabrielides, G. Pollution of the Mediterranean Sea, Water Science and Technology, Volume 32 (1995) no. 9-10, pp. 1-10 | DOI

[54] Genchi, G.; Carocci, A.; Lauria, G.; Sinicropi, M. S.; Catalano, A. Thallium Use, Toxicity, and Detoxification Therapy: An Overview, Applied Sciences, Volume 11 (2021) no. 18, p. 8322 | DOI

[55] Grosell, M. 2 - Copper, Homeostasis and Toxicology of Essential Metals (Fish Physiology), Volume 31, Academic Press, 2011, pp. 53-133 | DOI

[56] Guérin, T.; Chekri, R.; Vastel, C.; Sirot, V.; Volatier, J.-L.; Leblanc, J.-C.; Noël, L. Determination of 20 trace elements in fish and other seafood from the French market, Food Chemistry, Volume 127 (2011) no. 3, pp. 934-942 | DOI

[57] Guerra-García, J. M.; Calero-Cano, S.; Donázar-Aramendía, Í.; Giráldez, I.; Morales, E.; Arechavala-Lopez, P.; Cervera-Currado, J. L. Assessment of Elemental Composition in Commercial Fish of the Bay of Cádiz, Southern Iberian Peninsula, Marine Pollution Bulletin, Volume 187 (2023) no. November 2022, p. 114504 | DOI

[58] Guo, Z.; Zhang, W.; Du, S.; Green, I.; Tan, Q.; Zhang, L. Developmental Patterns of Copper Bioaccumulation in a Marine Fish Model Oryzias Melastigma, Aquatic Toxicology, Volume 170 (2016), pp. 216-222 | DOI

[59] Halliwell, B.; Gutteridge, J. M. C. Free Radicals in Biology and Medicine, Free Radicals in Biology and Medicine, Oxford University Press, 2015 | DOI

[60] Harmelin-Vivien, M.; Cossa, D.; Crochet, S.; Bǎnaru, D.; Letourneur, Y.; Mellon-Duval, C. Difference of Mercury Bioaccumulation in Red Mullets from the North-Western Mediterranean and Black Seas, Marine Pollution Bulletin, Volume 58 (2009) no. 5, pp. 679-685 | DOI

[61] Heys, K. A.; Shore, R. F.; Pereira, M. G.; Jones, K. C.; Martin, F. L. Risk Assessment of Environmental Mixture Effects, RSC Advances, Volume 6 (2016) no. 53, pp. 47844-47857 | DOI

[62] Hollis, L.; McGeer, J. C.; McDonald, D.; Wood, C. M. Cadmium Accumulation, Gill Cd Binding, Acclimation, and Physiological Effects during Long Term Sublethal Cd Exposure in Rainbow Trout, Aquatic Toxicology, Volume 46 (1999) no. 2, pp. 101-119 | DOI

[63] Isani, G.; Andreani, G.; Cocchioni, F.; Fedeli, D.; Carpené, E.; Falcioni, G. Cadmium Accumulation and Biochemical Responses in Sparus Aurata Following Sub-Lethal Cd Exposure, Ecotoxicology and Environmental Safety, Volume 72 (2009) no. 1, pp. 224-230 | DOI

[64] Jaishankar, M.; Tseten, T.; Anbalagan, N.; Mathew, B. B.; Beeregowda, K. N. Toxicity, Mechanism and Health Effects of Some Heavy Metals, Interdisciplinary Toxicology, Volume 7 (2014) no. 2, pp. 60-72 | DOI

[65] Javed, M.; Ahmad, M. I.; Usmani, N.; Ahmad, M. Multiple Biomarker Responses (Serum Biochemistry, Oxidative Stress, Genotoxicity and Histopathology) in Channa Punctatus Exposed to Heavy Metal Loaded Waste Water, Scientific Reports, Volume 7 (2017) no. 1, p. 1675 | DOI

[66] Jin, L.; Bi, Y.; Hu, C.; Qu, J.; Shen, S.; Wang, X.; Tian, Y. A Comparative Study of Evaluating Missing Value Imputation Methods in Label-Free Proteomics, Scientific Reports, Volume 11 (2021) no. 1, pp. 1-11 | DOI

[67] Joiris, C. R.; Holsbeek, L.; Moatemri, N. L. Total and Methylmercury in Sardines Sardinella Aurita and Sardina Pilchardus from Tunisia, Marine Pollution Bulletin, Volume 38 (1999) no. 3, pp. 188-192 | DOI

[68] Kardon, J. R.; Vale, R. D. Regulators of the Cytoplasmic Dynein Motor, Nature Reviews Molecular Cell Biology, Volume 10 (2009) no. 12, pp. 854-865 | DOI

[69] Karim, M.; Puiseux-Dao, S.; Edery, M. Toxins and Stress in Fish: Proteomic Analyses and Response Network, Toxicon : official journal of the International Society on Toxinology, Volume 57 (2011) no. 7-8, pp. 959-969 | DOI

[70] Kaushal, S. S.; Gold, A. J.; Bernal, S.; Johnson, T. A.; Addy, K.; Burgin, A.; Burns, D. A.; Coble, A. A.; Hood, E.; Lu, Y. H.; Mayer, P.; Minor, E. C.; Schroth, A. W.; Vidon, P.; Wilson, H.; Xenopoulos, M. A.; Doody, T.; Galella, J. G.; Goodling, P.; Haviland, K.; Haq, S.; Wessel, B.; Wood, K. L.; Jaworski, N.; Belt, K. T. Watershed `chemical Cocktails': Forming Novel Elemental Combinations in Anthropocene Fresh Waters, Biogeochemistry, Volume 141 (2018) no. 3, pp. 281-305 | DOI

[71] Koivula, M. J.; Eeva, T. Metal-Related Oxidative Stress in Birds, Environmental Pollution, Volume 158 (2010) no. 7, pp. 2359-2370 | DOI

[72] Kokla, M.; Virtanen, J.; Kolehmainen, M.; Paananen, J.; Hanhineva, K. Random Forest-Based Imputation Outperforms Other Methods for Imputing LC-MS Metabolomics Data: A Comparative Study, BMC Bioinformatics, Volume 20 (2019) no. 1, pp. 1-11 | DOI

[73] Kumari, B.; Kumar, V.; Sinha, A. K.; Ahsan, J.; Ghosh, A. K.; Wang, H.; DeBoeck, G. Toxicology of Arsenic in Fish and Aquatic Systems, Environmental Chemistry Letters, Volume 15 (2017) no. 1, pp. 43-64 | DOI

[74] Kumarswamy, R.; Chandna, S. Putative Partners in Bax Mediated Cytochrome-c Release: ANT, CypD, VDAC or None of Them?, Mitochondrion, Volume 9 (2009) no. 1, pp. 1-8 | DOI

[75] Langfelder, P.; Horvath, S. WGCNA: An R Package for Weighted Correlation Network Analysis, BMC Bioinformatics, Volume 9 (2008) no. 1, p. 559 | DOI

[76] Le Bourg, B.; Bănaru, D.; Saraux, C.; Nowaczyk, A.; Le Luherne, E.; Jadaud, A.; Bigot, J.; Richard, P. Trophic Niche Overlap of Sprat and Commercial Small Pelagic Teleosts in the Gulf of Lions (NW Mediterranean Sea), Journal of Sea Research, Volume 103 (2015), pp. 138-146 | DOI

[77] Leaver, M. J.; Diab, A.; Boukouvala, E.; Williams, T. D.; Chipman, J. K.; Moffat, C. F.; Robinson, C. D.; George, S. G. Hepatic Gene Expression in Flounder Chronically Exposed to Multiply Polluted Estuarine Sediment: Absence of Classical Exposure `biomarker' Signals and Induction of Inflammatory, Innate Immune and Apoptotic Pathways, Aquatic Toxicology, Volume 96 (2010) no. 3, pp. 234-245 | DOI

[78] Li, Y.; Wang, W.-X. Integrated transcriptomics and proteomics revealed the distinct toxicological effects of multi-metal contamination on oysters, Environmental Pollution, Volume 284 (2021) | DOI

[79] Liu, Y.; Shang, D.; Yang, Y.; Cui, P.; Sun, J. Transcriptomic Analysis Provides Insights into Microplastic and Heavy Metal Challenges in the Line Seahorse (Hippocampus Erectus), Fishes, Volume 7 (2022) no. 6 | DOI

[80] Lloret, J.; Shulman, G.; Love, R. M. Condition and Health Indicators of Exploited Marine Fishes, Condition and Health Indicators of Exploited Marine Fishes, John Wiley & Sons, Oxford, 2013, pp. 1-247 | DOI

[81] Lohner, T. W.; Reash, R. J.; Willet, V.; Rose, L. A. Assessment of Tolerant Sunfish Populations (Lepomis Sp.) Inhabiting Selenium-Laden Coal Ash Effluents, Ecotoxicology and Environmental Safety, Volume 50 (2001) no. 3, pp. 203-216 | DOI

[82] López-Pedrouso, M.; Varela, Z.; Franco, D.; Fernández, J.; Aboal, J. Can proteomics contribute to biomonitoring of aquatic pollution? A critical review, Environmental Pollution, Volume 267 (2020) | DOI

[83] Lozano-Bilbao, E.; Díaz, Y.; Lozano, G.; Jurado-Ruzafa, A.; Hardisson, A.; Rubio, C.; Jiménez, S.; González-Weller, D.; Gutiérrez, Á. J. Metal Content in Small Pelagic Fish in the North-West Africa, Thalassas: An International Journal of Marine Sciences, Volume 35 (2019) no. 2, pp. 643-653 | DOI

[84] Magulova, K.; Priceputu, A. Global Monitoring Plan for Persistent Organic Pollutants (POPs) under the Stockholm Convention: Triggering, Streamlining and Catalyzing Global POPs Monitoring, Environmental Pollution, Volume 217 (2016), pp. 82-84 | DOI

[85] McCuaig, L. M.; Martyniuk, C. J.; Marlatt, V. L. Morphometric and Proteomic Responses of Early-Life Stage Rainbow Trout (Oncorhynchus Mykiss) to the Aquatic Herbicide Diquat Dibromide, Aquatic Toxicology, Volume 222 (2020) | DOI

[86] Mela, M.; Randi, M.; Ventura, D.; Carvalho, C.; Pelletier, E.; Oliveira Ribeiro, C. Effects of Dietary Methylmercury on Liver and Kidney Histology in the Neotropical Fish Hoplias Malabaricus, Ecotoxicology and Environmental Safety, Volume 68 (2007) no. 3, pp. 426-435 | DOI

[87] Mitra, A.; Shevde, L. A.; Samant, R. S. Multi-Faceted Role of HSP40 in Cancer, Clinical & Experimental Metastasis, Volume 26 (2009) no. 6, pp. 559-567 | DOI

[88] Mollan, T. L.; Khandros, E.; Weiss, M. J.; Olson, J. S. Kinetics of α-Globin Binding to α-Hemoglobin Stabilizing Protein (AHSP) Indicate Preferential Stabilization of Hemichrome Folding Intermediate, Journal of Biological Chemistry, Volume 287 (2012) no. 14, pp. 11338-11350 | DOI

[89] Morcillo, P.; Esteban, M. Á.; Cuesta, A. Heavy metals produce toxicity, oxidative stress and apoptosis in the marine teleost fish SAF-1 cell line, Chemosphere, Volume 144 (2016), pp. 225-233 | DOI

[90] Moreira, C. Effects of Mercury on Myosin ATPase in the Ventricular Myocardium of the Rat, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Volume 135 (2003) no. 3, pp. 269-275 | DOI

[91] Moret, Y.; Schmid-Hempel, P. Survival for Immunity: The Price of Immune System Activation for Bumblebee Workers, Science, Volume 290 (2000) no. 5494, pp. 1166-1168 | DOI

[92] Parrish, C. C. Dissolved and Particulate Marine Lipid Classes: A Review, Marine Chemistry, Volume 23 (1988) no. 1-2, pp. 17-40 | DOI

[93] Paschal, B. M.; Shpetner, H. S.; Vallee, R. B. MAP 1C Is a Microtubule-Activated ATPase Which Translocates Microtubules in Vitro and Has Dynein-like Properties., The Journal of cell biology, Volume 105 (1987) no. 3, pp. 1273-1282 | DOI

[94] Pedrotti, M. L.; Petit, S.; Elineau, A.; Bruzaud, S.; Crebassa, J. C.; Dumontet, B.; Martí, E.; Gorsky, G.; Cózar, A. Changes in the Floating Plastic Pollution of the Mediterranean Sea in Relation to the Distance to Land, PLoS ONE, Volume 11 (2016) no. 8, pp. 1-14 | DOI

[95] Pereira, S.; Pinto, A. L.; Cortes, R.; Fontaínhas-Fernandes, A.; Coimbra, A. M.; Monteiro, S. M. Gill Histopathological and Oxidative Stress Evaluation in Native Fish Captured in Portuguese Northwestern Rivers, Ecotoxicology and Environmental Safety, Volume 90 (2013), pp. 157-166 | DOI

[96] Perez-Riverol, Y.; Csordas, A.; Bai, J.; Bernal-Llinares, M.; Hewapathirana, S.; Kundu, D. J.; Inuganti, A.; Griss, J.; Mayer, G.; Eisenacher, M.; Pérez, E.; Uszkoreit, J.; Pfeuffer, J.; Sachsenberg, T.; Yılmaz, Ş.; Tiwary, S.; Cox, J.; Audain, E.; Walzer, M.; Jarnuczak, A. F.; Ternent, T.; Brazma, A.; Vizcaíno, J. A. The PRIDE Database and Related Tools and Resources in 2019: Improving Support for Quantification Data, Nucleic Acids Research, Volume 47 (2019) no. D1, p. D442-D450 | DOI

[97] Plum, L. M.; Rink, L.; Hajo, H. The Essential Toxin: Impact of Zinc on Human Health, International Journal of Environmental Research and Public Health, Volume 7 no. 4, pp. 1342-1365 | DOI

[98] Queiros, Q.; Fromentin, J. M.; Astruc, G.; Bauer, R. K.; Saraux, C. Dolphin Predation Pressure on Pelagic and Demersal Fish in the Northwestern Mediterranean Sea, Marine Ecology Progress Series, Volume 603 (2018), pp. 13-27 | DOI

[99] Queiros, Q.; Fromentin, J. M.; Gasset, E.; Dutto, G.; Huiban, C.; Metral, L.; Leclerc, L.; Schull, Q.; McKenzie, D. J.; Saraux, C. Food in the Sea: Size Also Matters for Pelagic Fish, Frontiers in Marine Science, Volume 6 (2019) no. JUL, p. 385 | DOI

[100] Queiros, Q.; McKenzie, D. J.; Dutto, G.; Killen, S.; Saraux, C.; Schull, Q. Fish Shrinking, Energy Balance and Climate Change, Science of The Total Environment, Volume 906 (2024), p. 167310 | DOI

[101] Quque, M.; Brun, C.; Villette, C.; Sueur, C.; Criscuolo, F.; Heintz, D.; Bertile, F. Both Age and Social Environment Shape the Phenotype of Ant Workers, Scientific reports, Volume 13 (2023) no. 1, p. 186 | DOI

[102] R Core Team R: A Language and Environment for Statistical Computing, 2021 (https://www.r-project.org/)

[103] Radakovitch, O.; Roussiez, V.; Ollivier, P.; Ludwig, W.; Grenz, C.; Probst, J.-L. Input of Particulate Heavy Metals from Rivers and Associated Sedimentary Deposits on the Gulf of Lion Continental Shelf, Estuarine, Coastal and Shelf Science, Volume 77 (2008) no. 2, pp. 285-295 | DOI

[104] Regoli, F.; Giuliani, M. E. Oxidative Pathways of Chemical Toxicity and Oxidative Stress Biomarkers in Marine Organisms, Marine Environmental Research, Volume 93 (2014), pp. 106-117 | DOI

[105] Robledo Ardila, P. A.; Álvarez-Alonso, R.; Árcega-Cabrera, F.; Durán Valsero, J. J.; Morales García, R.; Lamas-Cosío, E.; Oceguera-Vargas, I.; DelValls, A. Assessment and Review of Heavy Metals Pollution in Sediments of the Mediterranean Sea, Applied Sciences, Volume 14 (2024) no. 4, p. 1435 | DOI

[106] Rodríguez‐Ortega, M. J.; Grøsvik, B. E.; Rodríguez‐Ariza, A.; Goksøyr, A.; López‐Barea, J. Changes in protein expression profiles in bivalve molluscs (Chamaelea gallina) exposed to four model environmental pollutants, Proteomics, Volume 3 (2003) no. 8, pp. 1535-1543 | DOI

[107] Romero, D.; Barcala, E.; María-Dolores, E.; Muñoz, P. European Eels and Heavy Metals from the Mar Menor Lagoon (SE Spain), Marine Pollution Bulletin, Volume 158 (2020) no. June, p. 111368 | DOI

[108] Sacks, F. M. The Apolipoprotein Story, Atherosclerosis Supplements, Volume 7 (2006) no. 4, pp. 23-27 | DOI

[109] Sakuragui, M. M.; Paulino, M. G.; Pereira, C. D.; Carvalho, C. S.; Sadauskas-Henrique, H.; Fernandes, M. N. Integrated Use of Antioxidant Enzymes and Oxidative Damage in Two Fish Species to Assess Pollution in Man-Made Hydroelectric Reservoirs, Environmental Pollution, Volume 178 (2013), pp. 41-51 | DOI

[110] Sánchez-Marín, P.; Vidal-Liñán, L.; Fernández-González, L. E.; Montes, R.; Rodil, R.; Quintana, J. B.; Carrera, M.; Mateos, J.; Diz, A. P.; Beiras, R. Proteomic Analysis and Biochemical Alterations in Marine Mussel Gills after Exposure to the Organophosphate Flame Retardant TDCPP, Aquatic Toxicology, Volume 230 (2021) | DOI

[111] Sanchez, B. C.; Ralston-Hooper, K.; Sepúlveda, M. S. Review of Recent Proteomic Applications in Aquatic Toxicology, Environmental Toxicology and Chemistry, Volume 30 (2011) no. 2, pp. 274-282 | DOI

[112] Santos, C. R.; Schulze, A. Lipid Metabolism in Cancer, The FEBS Journal, Volume 279 (2012) no. 15, pp. 2610-2623 | DOI

[113] Saraux, C.; Van Beveren, E.; Brosset, P.; Queiros, Q.; Bourdeix, J.-H.; Dutto, G.; Gasset, E.; Jac, C.; Bonhommeau, S.; Fromentin, J.-M. Small Pelagic Fish Dynamics: A Review of Mechanisms in the Gulf of Lions, Deep Sea Research Part II: Topical Studies in Oceanography, Volume 159 (2019), pp. 52-61 | DOI

[114] Sardenne, F.; Bodin, N.; Metral, L.; Crottier, A.; Le Grand, F.; Bideau, A.; Brisset, B.; Bourjea, J.; Saraux, C.; Bonhommeau, S.; Kerzérho, V.; Bernard, S.; Rouyer, T. Effects of Extraction Method and Storage of Dry Tissue on Marine Lipids and Fatty Acids, Analytica Chimica Acta, Volume 1051 (2019) no. November, pp. 82-93 | DOI

[115] Sharma, S.; Sharma, V.; Chatterjee, S. Microplastics in the Mediterranean Sea : Sources , Pollution Intensity , Sea Health , and Regulatory Policies, Frontiers in Marine Science, Volume 8 (2021) no. May, pp. 1-15 | DOI

[116] Si, L. F.; Wang, C. C.; Guo, S. N.; Zheng, J. L.; Xia, H. The Lagged Effects of Environmentally Relevant Zinc on Non-Specific Immunity in Zebrafish, Chemosphere, Volume 214 (2019), pp. 85-93 | DOI

[117] Souid, G.; Souayed, N.; Yaktiti, F.; Maaroufi, K. Lead Accumulation Pattern and Molecular Biomarkers of Oxidative Stress in Seabream ( Sparus Aurata ) under Short-Term Metal Treatment, Drug and Chemical Toxicology, Volume 38 (2015) no. 1, pp. 98-105 | DOI

[118] Strady, E.; Harmelin-Vivien, M.; Chiffoleau, J. F.; Veron, A.; Tronczynski, J.; Radakovitch, O. 210 Po and 210 Pb Trophic Transfer within the Phytoplankton–Zooplankton–Anchovy/Sardine Food Web: A Case Study from the Gulf of Lion (NW Mediterranean Sea), Journal of Environmental Radioactivity, Volume 143 (2015), pp. 141-151 | DOI

[119] Tang, W. L.; Evans, D.; Kraemer, L.; Zhong, H. Body Size-Dependent Cd Accumulation in the Zebra Mussel Dreissena Polymorpha from Different Routes, Chemosphere, Volume 168 (2017), pp. 825-831 | DOI

[120] Tchounwou, P. B.; Yedjou, C. G.; Patlolla, A. K.; Sutton, D. J. Heavy Metal Toxicity and the Environment, Molecular, Clinical and Environmental Toxicology: Volume 3: Environmental Toxicology, Springer Basel, Basel, 2012, pp. 133-164 | DOI

[121] Teulier, L.; Thoral, E.; Queiros, Q.; McKenzie, D. J.; Roussel, D.; Dutto, G.; Gasset, E.; Bourjea, J.; Saraux, C. Muscle Bioenergetics of Two Emblematic Mediterranean Fish Species: Sardina Pilchardus and Sparus Aurata, Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, Volume 235 (2019) no. June, pp. 174-179 | DOI

[122] Tocher, D. R. Metabolism and Functions of Lipids and Fatty Acids in Teleost Fish, Reviews in fisheries science, Volume 11, 2003 no. 2, pp. 107-184 | DOI

[123] Tournois, J.; Darnaude, A. M.; Ferraton, F.; Aliaume, C.; Mercier, L.; McKenzie, D. J. Lagoon Nurseries Make a Major Contribution to Adult Populations of a Highly Prized Coastal Fish, Limnology and Oceanography, Volume 62 (2017) no. 3, pp. 1219-1233 | DOI

[124] Tronczynski, J.; Carlotti, F.; Bodin, N.; Radakovitch, O. Contaminants Bioaccumulation and Biomagnification in a Short Trophic System: Phytoplankton, Zooplankton, Anchovy, Sardine (COSTAS), Ciesm (2013)

[125] Van Beveren, E.; Bonhommeau, S.; Fromentin, J. M.; Bigot, J. L.; Bourdeix, J. H.; Brosset, P.; Roos, D.; Saraux, C. Rapid Changes in Growth, Condition, Size and Age of Small Pelagic Fish in the Mediterranean, Marine Biology, Volume 161 (2014) no. 8, pp. 1809-1822 | DOI

[126] Van Beveren, E.; Fromentin, J.-M.; Bonhommeau, S.; Nieblas, A.-E.; Metral, L.; Brisset, B.; Jusup, M.; Bauer, R. K.; Brosset, P.; Saraux, C. Predator–Prey Interactions in the Face of Management Regulations: Changes in Mediterranean Small Pelagic Species Are Not Due to Increased Tuna Predation, Canadian Journal of Fisheries and Aquatic Sciences, Volume 74 (2017) no. 9, pp. 1422-1430 | DOI

[127] Van Beveren, E.; Fromentin, J.-m.; Rouyer, T.; Bonhommeau, S.; Brosset, P.; Saraux, C. The Fisheries History of Small Pelagics in the Northern Mediterranean, ICES Journal of Marine Science, Volume 73 (2016) no. 6, pp. 1474-1484 | DOI

[128] Van Beveren, E.; Keck, N.; Fromentin, J.-M.; Laurence, S.; Boulet, H.; Labrut, S.; Baud, M.; Bigarré, L.; Brosset, P.; Saraux, C. Can Pathogens Alter the Population Dynamics of Sardine in the NW Mediterranean?, Marine Biology, Volume 163 (2016) no. 12, p. 240 | DOI

[129] van Meer, G.; Voelker, D. R.; Feigenson, G. W. Membrane lipids: where they are and how they behave, Nature Reviews Molecular Cell Biology, Volume 9 (2008) no. 2, pp. 112-124 | DOI

[130] Verbovsek, T. A Comparison of Parameters below the Limit of Detection in Geochemical Analyses by Substitution Methods, RMZ – Materials and Geoenvironment, Volume 58 (2011) no. 4, pp. 393-404

[131] Vignati, D. A. L.; Hanano, A. Molecular-level responses highlight physiological stress in muscle and liver tissue of apparently healthy European sardine specimen, Peer Community in Ecotoxicology and Environmental Chemistry (2024) | DOI

[132] Wang, L.; Gallagher, E. P. Role of Nrf2 Antioxidant Defense in Mitigating Cadmium-Induced Oxidative Stress in the Olfactory System of Zebrafish, Toxicology and Applied Pharmacology, Volume 266 (2013) no. 2, pp. 177-186 | DOI

[133] Wang, M.; Wang, Y.; Zhang, L.; Wang, J.; Hong, H.; Wang, D. Quantitative Proteomic Analysis Reveals the Mode-of-Action for Chronic Mercury Hepatotoxicity to Marine Medaka (Oryzias Melastigma), Aquatic Toxicology, Volume 130–131 (2013), pp. 123-131 | DOI

[134] Wijesooriya, K.; Jadaan, S. A.; Perera, K. L.; Kaur, T.; Ziemann, M. Urgent Need for Consistent Standards in Functional Enrichment Analysis, PLOS Computational Biology, Volume 18 (2022) no. 3, pp. 1-14 | DOI

[135] Williams, C. R.; Yoshida-Honmachi, E. P. Effects of Cadmium on Olfactory Mediated Behaviors and Molecular Biomarkers in Coho Salmon (Oncorhynchus Kisutch), Aquatic Toxicology, Volume 140–141 (2013), pp. 295-302 | DOI

[136] Xu, L.; Lu, Z.; Ji, C.; Cong, M.; Li, F.; Shan, X.; Wu, H. Toxicological Effects of As (V) in Juvenile Rockfish Sebastes Schlegelii by a Combined Metabolomic and Proteomic Approach, Environmental Pollution, Volume 255 (2019), p. 113333 | DOI

[137] Yadetie, F.; Karlsen, O. A.; Lanzén, A.; Berg, K.; Olsvik, P.; Hogstrand, C.; Goksøyr, A. Global Transcriptome Analysis of Atlantic Cod (Gadus Morhua) Liver after in Vivo Methylmercury Exposure Suggests Effects on Energy Metabolism Pathways, Aquatic Toxicology, Volume 126 (2013), pp. 314-325 | DOI

[138] Yin, S.; Liu, L.; Gan, W. The Roles of Post-Translational Modifications on mTOR Signaling, International Journal of Molecular Sciences, Volume 22 (2021) no. 4 | DOI

[139] Zhol, S.; Ackman, R. G.; Morrison, C. Storage of Lipids in the Myosepta of Atlantic Salmon (Salmo Salar), Fish Physiology and Biochemistry, Volume 14 (1995) no. 2, pp. 171-178 | DOI

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