Section: Evolutionary Biology
Topic: Evolution, Genetics/Genomics, Population biology

The fate of recessive deleterious or overdominant mutations near mating-type loci under partial selfing

10.24072/pcjournal.238 - Peer Community Journal, Volume 3 (2023), article no. e14.

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Large regions of suppressed recombination having extended over time occur in many organisms around genes involved in mating compatibility (sex-determining or mating-type genes). The sheltering of deleterious alleles has been proposed to be involved in such expansions. However, the dynamics of deleterious mutations partially linked to genes involved in mating compatibility are not well understood, especially in finite populations. In particular, under what conditions deleterious mutations are likely to be maintained for long enough near mating-compatibility genes remains to be evaluated, especially under selfing, which generally increases the purging rate of deleterious mutations. Using a branching process approximation, we studied the fate of a new deleterious or overdominant mutation in a diploid population, considering a locus carrying two permanently heterozygous mating-type alleles, and a partially linked locus at which the mutation appears. We obtained analytical and numerical results on the probability and purging time of the new mutation. We investigated the impact of recombination between the two loci and of the mating system (outcrossing, intra and inter-tetrad selfing) on the maintenance of the mutation. We found that the presence of a fungal-like mating-type locus (i.e. not preventing diploid selfing) always sheltered the mutation under selfing, i.e. it decreased the purging probability and increased the purging time of the mutations. The sheltering effect was higher in case of automixis (intra-tetrad selfing). This may contribute to explain why evolutionary strata of recombination suppression near the mating-type locus are found mostly in automictic (pseudo-homothallic) fungi. We also showed that rare events of deleterious mutation maintenance during strikingly long evolutionary times could occur, suggesting that deleterious mutations can indeed accumulate near the mating-type locus over evolutionary time scales. In conclusion, our results show that, although selfing purges deleterious mutations, these mutations can be maintained for very long times near a mating-type locus, which may contribute to promote the evolution of recombination suppression in sex-related chromosomes.

Published online:
DOI: 10.24072/pcjournal.238
Type: Research article

Tezenas, Emilie 1, 2, 3; Giraud, Tatiana 1; Véber, Amandine 3; Billiard, Sylvain 2

1 Université Paris-Saclay, CNRS, AgroParisTech, Ecologie Systematique et Evolution, 91190, Gif-sur-Yvette, France
2 Univ. Lille, CNRS, UMR 8198 - Evo-Eco-Paleo, F-59000 Lille, France
3 Université Paris Cité, CNRS, MAP 5, F-75006 Paris
License: CC-BY 4.0
Copyrights: The authors retain unrestricted copyrights and publishing rights
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Tezenas, Emilie; Giraud, Tatiana; Véber, Amandine; Billiard, Sylvain. The fate of recessive deleterious or overdominant mutations near mating-type loci under partial selfing. Peer Community Journal, Volume 3 (2023), article  no. e14. doi : 10.24072/pcjournal.238.

PCI peer reviews and recommendation, and links to data, scripts, code and supplementary information: 10.24072/pci.evolbiol.100635

Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.

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