Section: Evolutionary Biology
Topic: Evolution, Genetics/Genomics, Population biology

Phenotypic stasis with genetic divergence

10.24072/pcjournal.349 - Peer Community Journal, Volume 3 (2023), article no. e119.

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Whether or not genetic divergence in the short-term of tens to hundreds of generations is compatible with phenotypic stasis remains a relatively unexplored problem. We evolved predominantly outcrossing, genetically diverse populations of the nematode Caenorhabditis elegans under a constant and homogeneous environment for 240 generations and followed individual locomotion behavior. Although founders of lab populations show highly diverse locomotion behavior, during lab evolution, the component traits of locomotion behavior – defined as the transition rates in activity and direction – did not show divergence from the ancestral population. In contrast, transition rates’ genetic (co)variance structure showed a marked divergence from the ancestral state and differentiation among replicate populations during the final 100 generations and after most adaptation had been achieved. We observe that genetic differentiation is a transient pattern during the loss of genetic variance along phenotypic dimensions under drift during the last 100 generations of lab evolution. These results suggest that short-term stasis of locomotion behavior is maintained because of stabilizing selection, while the genetic structuring of component traits is contingent upon drift history.

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DOI: 10.24072/pcjournal.349
Type: Research article
Keywords: phenotypic stasis, G-matrix, selection surface, genetic drift, locomotion behavior, transition rates, Caenorhabditis elegans, experimental evolution, phenotypic stasis, G-matrix, selection surface, genetic drift, locomotion behavior, transition rates, Caenorhabditis elegans, experimental evolution, phenotypic stasis, G-matrix, selection surface, genetic drift, locomotion behavior, transition rates, Caenorhabditis elegans, experimental evolution

Mallard, François 1; Noble, Luke 1; Guzella, Thiago 1; Afonso, Bruno 1; Baer, Charles F. 2; Teotónio, Henrique 1

1 Institut de Biologie de l’École Normale Supérieure, CNRS UMR 8197, Inserm U1024, PSL Research University, F-75005 Paris, France
2 Department of Biology, University of Florida Genetics Institute, University of Florida, Gainsville, Florida 32611, U.S.A.
License: CC-BY 4.0
Copyrights: The authors retain unrestricted copyrights and publishing rights
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Mallard, François; Noble, Luke; Guzella, Thiago; Afonso, Bruno; Baer, Charles F.; Teotónio, Henrique. Phenotypic stasis with genetic divergence. Peer Community Journal, Volume 3 (2023), article  no. e119. doi : 10.24072/pcjournal.349.

PCI peer reviews and recommendation, and links to data, scripts, code and supplementary information: 10.24072/pci.evolbiol.100627

Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.

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