Section: Evolutionary Biology
Topic:
Evolution,
Genetics/Genomics,
Population biology
Introgression between highly divergent sea squirt genomes: an adaptive breakthrough?
Corresponding author(s): Fraïsse, Christelle (christelle.fraisse@univ-lille.fr)
10.24072/pcjournal.172 - Peer Community Journal, Volume 2 (2022), article no. e54.
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Human-mediated introductions are reshuffling species distribution on a global scale. Consequently, an increasing number of allopatric taxa are now brought into contact, promoting introgressive hybridization between incompletely isolated species and new adaptive gene transfer. The broadcast spawning marine species, Ciona robusta, has been recently introduced in the native range of its sister taxa, Ciona intestinalis, in the English Channel and North-East Atlantic. These sea squirts are highly divergent, yet hybridization has been reported by crossing experiments and genetic studies in the wild. Here, we examined the consequences of secondary contact between C. intestinalis and C. robusta in the English Channel. We produced genomes phased by transmission to infer the history of divergence and gene flow, and analyzed introgressed genomic tracts. Demographic inference revealed a history of secondary contact with a low overall rate of introgression. Introgressed tracts were short, segregating at low frequency, and scattered throughout the genome, suggesting traces of past contacts during the last 30 ky. However, we also uncovered a hotspot of introgression on chromosome 5, characterized by several hundred kb-long C. robusta haplotypes segregating in C. intestinalis, that introgressed during contemporary times the last 75 years. Although locally more frequent than the baseline level of introgression, C. robusta alleles are not fixed, even in the core region of the introgression hotspot. Still, linkage-disequilibrium patterns and haplotype-based tests suggest this genomic region is under recent positive selection. We further detected in the hotspot an over-representation of candidate SNPs lying on a cytochrome P450 gene with a high copy number of tandem repeats in the introgressed alleles. Cytochromes P450 are a superfamily of enzymes involved in detoxifying exogenous compounds, constituting a promising avenue for functional studies. These findings support that introgression of an adaptive allele is possible between very divergent genomes and that anthropogenic hybridization can provide the raw material for adaptation of native lineages in the Anthropocene.
Type: Research article
Fraïsse, Christelle 1, 2; Le Moan, Alan 3, 4; Roux, Camille 1; Dubois, Guillaume 3; Daguin-Thiebaut, Claire 3; Gagnaire, Pierre-Alexandre 2; Viard, Frédérique 2, 3; Bierne, Nicolas 2
CC-BY 4.0
@article{10_24072_pcjournal_172,
author = {Fra{\"\i}sse, Christelle and Le Moan, Alan and Roux, Camille and Dubois, Guillaume and Daguin-Thiebaut, Claire and Gagnaire, Pierre-Alexandre and Viard, Fr\'ed\'erique and Bierne, Nicolas},
title = {Introgression between highly divergent sea squirt genomes: an adaptive breakthrough?},
journal = {Peer Community Journal},
eid = {e54},
publisher = {Peer Community In},
volume = {2},
year = {2022},
doi = {10.24072/pcjournal.172},
url = {https://peercommunityjournal.org/articles/10.24072/pcjournal.172/}
}
TY - JOUR AU - Fraïsse, Christelle AU - Le Moan, Alan AU - Roux, Camille AU - Dubois, Guillaume AU - Daguin-Thiebaut, Claire AU - Gagnaire, Pierre-Alexandre AU - Viard, Frédérique AU - Bierne, Nicolas TI - Introgression between highly divergent sea squirt genomes: an adaptive breakthrough? JO - Peer Community Journal PY - 2022 VL - 2 PB - Peer Community In UR - https://peercommunityjournal.org/articles/10.24072/pcjournal.172/ DO - 10.24072/pcjournal.172 ID - 10_24072_pcjournal_172 ER -
%0 Journal Article %A Fraïsse, Christelle %A Le Moan, Alan %A Roux, Camille %A Dubois, Guillaume %A Daguin-Thiebaut, Claire %A Gagnaire, Pierre-Alexandre %A Viard, Frédérique %A Bierne, Nicolas %T Introgression between highly divergent sea squirt genomes: an adaptive breakthrough? %J Peer Community Journal %D 2022 %V 2 %I Peer Community In %U https://peercommunityjournal.org/articles/10.24072/pcjournal.172/ %R 10.24072/pcjournal.172 %F 10_24072_pcjournal_172
Fraïsse, Christelle; Le Moan, Alan; Roux, Camille; Dubois, Guillaume; Daguin-Thiebaut, Claire; Gagnaire, Pierre-Alexandre; Viard, Frédérique; Bierne, Nicolas. Introgression between highly divergent sea squirt genomes: an adaptive breakthrough?. Peer Community Journal, Volume 2 (2022), article no. e54. doi : 10.24072/pcjournal.172. https://peercommunityjournal.org/articles/10.24072/pcjournal.172/
PCI peer reviews and recommendation, and links to data, scripts, code and supplementary information: 10.24072/pci.evolbiol.100149
Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.
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