Evolutionary Biology

How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality

10.24072/pcjournal.322 - Peer Community Journal, Volume 3 (2023), article no. e92.

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Exchange of genetic material through sexual reproduction or horizontal gene transfer is ubiquitous in nature. Among the few outliers that rarely recombine and mainly evolve by de novo mutation are a group of deadly bacterial pathogens, including the causative agents of leprosy, plague, typhoid, and tuberculosis. The interplay of evolutionary processes is poorly understood in these organisms. Population genetic methods allowing to infer mutation, recombination, genetic drift, and natural selection make strong assumptions that are difficult to reconcile with clonal reproduction and fully linked genomes consisting mainly of coding regions. In this review, we highlight the challenges of extreme clonality by discussing population genetic inference with the Mycobacterium tuberculosis complex, a group of closely related obligate bacterial pathogens of mammals. We show how uncertainties underlying quantitative models and verbal arguments affect previous conclusions about the way these organisms evolve. A question mark remains behind various quantities of applied and theoretical interest, including mutation rates, the interpretation of nonsynonymous polymorphisms, or the role of genetic bottlenecks. Looking ahead, we discuss how new tools for evolutionary simulations, going beyond the traditional Wright-Fisher framework, promise a more rigorous treatment of basic evolutionary processes in clonal bacteria.

Published online:
DOI: 10.24072/pcjournal.322
Keywords: clonality, mutation, recombination, genetic drift, natural selection, simulation
Stritt, Christoph 1, 2; Gagneux, Sebastien 1, 2

1 Swiss Tropical and Public Health Institute, Allschwil, Switzerland
2 University of Basel, Basel, Switzerland
License: CC-BY 4.0
Copyrights: The authors retain unrestricted copyrights and publishing rights
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Stritt, Christoph; Gagneux, Sebastien. How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality. Peer Community Journal, Volume 3 (2023), article  no. e92. doi : 10.24072/pcjournal.322. https://peercommunityjournal.org/articles/10.24072/pcjournal.322/

Peer reviewed and recommended by PCI : 10.24072/pci.evolbiol.100644

Conflict of interest of the recommender and peer reviewers:
The recommender in charge of the evaluation of the article and the reviewers declared that they have no conflict of interest (as defined in the code of conduct of PCI) with the authors or with the content of the article.

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